Ca channel gating during cardiac action potentials
نویسندگان
چکیده
منابع مشابه
Subtype-Specific Effects on Ca Channel Gating
Ca channel subunits are important molecular determinants of the kinetics and voltage dependence of Ca channel gating. Through direct interactions with channel-forming 1 subunits, subunits enhance expression levels, accelerate activation, and have variable effects on inactivation. Four distinct subunit genes each encode five homologous sequence domains (D1–5), three of which (D1, D3, and D5) und...
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Na(+)-Ca(2+) exchange (NCX) is crucial in the regulation of [Ca(2+)](i) and cardiac contractility, but key details of its dynamic function during the heartbeat are not known. In the present study, we assess how NCX current (I(NCX)) varies during a rabbit ventricular action potential (AP). First, we measured the steady-state voltage and [Ca(2+)](i) dependence of I(NCX) under conditions when [Ca(...
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Na-Ca exchange (NCX) is crucial in the regulation of [Ca]i and cardiac contractility, but key details of its dynamic function during the heartbeat are not known. In the present study, we assess how NCX current (INCX) varies during a rabbit ventricular action potential (AP). First, we measured the steady-state voltage and [Ca]i dependence of INCX under conditions when [Ca ]i was heavily buffered...
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Na -Ca exchange (NCX) is crucial in the regulation of [Ca ]i and cardiac contractility, but key details of its dynamic function during the heartbeat are not known. In the present study, we assess how NCX current (INCX) varies during a rabbit ventricular action potential (AP). First, we measured the steady-state voltage and [Ca ]i dependence of INCX under conditions when [Ca 2 ]i was heavily buf...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1990
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(90)82448-6